(+)-Ketoconazole

SKU: orb2946027

Description

(+)-Ketoconazole ((+)-R 41400) is a potent CYP3A4 inhibitor and broad-spectrum antifungal agent. It is widely used in research for studying fungal pathogenesis and seborrheic dermatitis, serving as a critical tool in both in vitro enzyme assays and in vivo pharmacological models.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 142128-59-4
• MW: 531.43
• Purity: 99.79%
• Formula: C₂₆H₂₈Cl₂N₄O₄
• SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)=O)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5
• Target: Antifungal,Cytochromes P450
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.76 mM);DMSO:20 mg/mL (37.63 mM)

Bioactivity

• In Vivo:
  Perinatal exposure of female rats to (+)-Ketoconazole (3-6-12mg/kg.d), adolescence or adulthood (3-12-48mg/kg.d) showed that perinatal exposure to the highest dose of (+)-Ketoconazole delayed the maturation of GnRH secretion before puberty, while adolescent or adult exposure had no effect on GnRH pulsation.
• In Vitro:
  (+)-Ketoconazole, an imidazole derivative, is a broad-spectrum systemic antifungal agent with oral activity that effectively inhibits CYP3A4 activity in human liver microsomes.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(+) Ketoconazole, (+)-R 41400, (+)-R41400, (+)-Ketoconazol, (+)Ketoconazole

Compound Identifiers

PubChem CID

456201