JNJ-42165279

SKU: orb1304416

Description

JNJ-42165279 is a highly selective covalent inhibitor of the FAAH enzyme, demonstrating no significant activity (>50% inhibition at 10 µM) against a broad panel of 50 off-targets, including key CYPs and the hERG channel. This selectivity profile supports its utility as a precise pharmacological tool for in vitro and in vivo research investigating the endocannabinoid system, pain, and mood disorders.

Research Area

Cell Biology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 1346528-50-4
• MW: 410.8
• Purity: 99.89%
• Formula: C₁₈H₁₇ClF₂N₄O₃
• SMILES: FC1(F)Oc2ccc(CN3CCN(CC3)C(=O)Nc3cnccc3Cl)cc2O1
• Target: FAAH,Autophagy
• Solubility: DMSO:45 mg/mL (109.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (6.09 mM)

Bioactivity

• Target IC50:
  FAAH (human):70 ± 8 nM|FAAH (rat):313 ± 28 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

rFAAH, inhibit, JNJ 42165279, JNJ42165279, JNJ-42165279, Inhibitor, hFAAH, Fatty acid amide hydrolase, FAAH, Autophagy

Compound Identifiers

PubChem CID

54576693