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JNJ-42165279

SKU: orb1226487

Description

JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH; no inhibition on CYPs and hERG at 10 uM; blocks FAAH in the brain and periphery of rats , causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties.Anxiety Phase 2 Clinical.

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Key Properties

CAS Number1346528-50-4
MW410.8024
Purity>98% (HPLC)
FormulaC18H17ClF2N4O3
SMILESC1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl
TargetFAAH
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JNJ42165279 | JNJ 42165279

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JNJ-42165279 (orb1226487)

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Available Sizes

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2 mg
$ 110.00
5 mg
$ 160.00
10 mg
$ 220.00
25 mg
$ 400.00
50 mg
$ 580.00
100 mg
$ 840.00
200 mg
$ 1,180.00
500 mg
$ 1,750.00