(-)-JJ-450

SKU: orb3136157

Description

(-)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR). It is more effective than (+)-JJ-450 in inhibiting androgen-induced AR activity, while (+)-JJ-450 inhibits AR via a mechanism distinct from Enzalutamide (MDV3100), possibly targeting the ligand-binding domain (LBD) of AR. (-)-JJ-450 inhibits transcriptional activity of both wild-type AR and the mutant ARF876L by suppressing AR nuclear translocation and promoting intranuclear degradation of unbound AR. This compound can be utilized in research focusing on castration-resistant prostate cancer (CRPC) that is resistant to Enzalutamide.

Key Properties

• CAS Number: 1998094-23-7
• MW: 372.86
• Formula: C₂₁H₂₂ClFN₂O
• SMILES: C(=O)([C@@H]1[C@@H](C1)C2=CC=C(F)C=C2)N3CCN(CC3)C4=C(C)C=CC(Cl)=C4
• Target: Androgen Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Androgen Receptor