(+)-JJ-450

SKU: orb3135402

Description

(+)-JJ-450 is a non-competitive antagonist that targets the androgen receptor (AR), inhibiting nuclear localization and transcriptional activity of AR under androgen-deprived conditions. In LN95 cells, (+)-JJ-450 is less effective than (-)-JJ-450 at inhibiting prostate-specific antigen (PSA) expression, likely due to its targeting of the AR ligand-binding domain (LBD). The compound works by promoting degradation of unbound AR within the nucleus and reducing AR binding to androgen response elements (AREs), thus inhibiting the transcriptional activity of AR and its splicing variants like ARv7. Additionally, (+)-JJ-450 is applicable for research in castration-resistant prostate cancer (CRPC) that is resistant to Enzalutamide (MDV3100).

Key Properties

• CAS Number: 1998094-24-8
• MW: 372.86
• Formula: C₂₁H₂₂ClFN₂O
• SMILES: C(=O)([C@H]1[C@H](C1)C2=CC=C(F)C=C2)N3CCN(CC3)C4=C(C)C=CC(Cl)=C4
• Target: Androgen Receptor,Prostaglandin Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Androgen Receptor,Prostaglandin Receptor