JB300

SKU: orb2945864

Description

JB300 is a potent and selective PROTAC degrader of Aurora A kinase (DC50 = 30 nM), composed of the MK-5108 ligand, a PEG2 linker, and a Thalidomide-based E3 ligase recruiter. It is a valuable chemical tool for probing Aurora A biology and exploring targeted protein degradation strategies in cancer research, applicable in both cellular and in vivo models.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3038446-90-8
• MW: 906.375
• Formula: C₄₃H₄₅ClFN₇O₁₀S
• SMILES: C([C@@]1(C(NCCOCCOCCNC(COC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)=O)=O)CC[C@@H](OC5=C(F)C(Cl)=CC=C5)CC1)C=6N=C(NC7=NC=CS7)C=CC6
• Target: PROTACs,Aurora Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171329199