J147

SKU: orb1226914

Description

J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).(In Vitro):J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06-0.115 μM) .(In Vivo):J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.The half life (t1/2) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).

Key Properties

• CAS Number: 1146963-51-0
• MW: 350.34
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₇F₃N₂O₂
• SMILES: O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F
• Target: Epigenetic Reader Domain
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  Animal model: 24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls. Dosage: 200 ppm. Administration: The diet was prepared by the addition of 200ppm; 6 months. Result: While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

J147 | J 147 | J-147

Quick Database Links

Gene Symbol

Epigenetic Reader Domain