J-147

SKU: orb1306813

Description

J-147 is a synthetic curcumin derivative developed as a neuroprotective and neurogenic research compound. It has shown efficacy in preclinical models of aging, Alzheimer's disease, and diabetic neuropathy, impacting multiple relevant pathways. Studies include both in vitro assays and in vivo experiments using accelerated aging mouse models.

Research Area

Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1146963-51-0
• MW: 350.33
• Purity: 100.00%
• Formula: C₁₈H₁₇F₃N₂O₂
• SMILES: COc1cccc(\C=N\N(C(=O)C(F)(F)F)c2ccc(C)cc2C)c1
• Target: Dopamine Receptor,Monoamine Oxidase,Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.85 mM);DMSO:45 mg/mL (128.45 mM)

Bioactivity

• Target IC50:
  Neuroprotection:60-115 nM(EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SLC6A3, oxidase, transporte, Alzheimer, barrier, BBB, BDNF, brain, blood, disease, dopamine, DopamineReceptor, Dopamine Transporter, Dopamine Receptor, DAT, inhibit, J147, J-147, J 147, MonoamineOxidase, Monoamine Oxidase, monoamine, neuroprotective, MAO, MAO B, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain

Compound Identifiers

PubChem CID

25229652