Ipriflavone

SKU: orb1310736

Description

Ipriflavone

Key Properties

• CAS Number: 35212-22-7
• MW: 280.32
• Purity: 99.60%
• Formula: C₁₈H₁₆O₃
• SMILES: CC(C)OC1=CC2=C(C=C1)C(=O)C(=CO2)C1=CC=CC=C1
• Target: Advanced Glycation End Products,Others
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (8.92 mM);Ethanol:2 mg/mL (7.13 mM);DMSO:60 mg/mL (214.04 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Ipriflavone modulate the differentiation and biosynthesis of human bone marrow stromal osteoprogenitor cells (BMCs) by enhancin the expression of certain key matrix proteins and promoting mineralization. In cultured murine undifferentiated osteoblasts, 10 mM Ipriflavone significantly inhibits bone resorption augmented by glycation end products. At a 50 mM dose, Ipriflavone does not induce apoptosis in MDA-231 cells. Additionally, Ipriflavone exhibits a dose-dependent Inhibition of MDA-231 cell proliferation and DNA synthesis and impedes li and-induced phosphorylation of Tyr845 in the EGFR.
• In Vitro:
  Ipriflavone significantly inhibit the growth of MDA-231 xenograft tumors; treated mice exhibited a reduction in tumor volume by 25% and 45% and a decrease in weight by 47% and 63% compared to the control group, respectively along with extended survival times o the tumor-bearing mice. Additionally, oral administration of 12 mg of Ipriflavone markedly suppresse the development of osteolytic metastases in bone metastatic cancer, impede the progression of osteolytic lesions, and reduce the number of osteoclasts adjacent to cancer cells.
• Cell Research:
  Cells are exposed to various concentration of Ipriflavone for 24, 48, 72 and 96 hours. Cells are treated with trypan blue to estimat the number of viable cells. For thymidine incorporation analysis, [3H]Thymidine (1 μCi) is added, and cells are Harvested onto glass fiber filters 4 hours later. Radioactivity is determined by scintillation counting.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

advancedglycationendproducts, advanced glycation end products, Inhibitor, inhibit, Ipriflavone, Osteofix

Compound Identifiers

PubChem CID

3747