Ipriflavone

SKU: orb1225226

Description

Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption.(In Vitro):Ipriflavone inhibits the proliferation and DNA synthesis of MDA-231 cells and blocks the ligand-induced phosphorylation of Tyr(845) of the EGFR. Ipriflavone does not promote apoptosis of MDA-231 cells. Ipriflavone also promotes the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like cells as well as the activity of alkaline phosphatase.\n(In Vivo):Daily oral administration of ipriflavone at 12 mg/mouse significantly inhibits the development of new osteolytic bone metastases and the progression of established osteolytic lesions, prolonging the life of tumor-bearing mice. Ipriflavone reduces the number of osteoclasts at the bone-cancer interface with no severe adverse effects on the host. 1-month treatment with ipriflavone increases bone density and improves the biomechanical properties of adult rat male bones without altering mineral composition.

Key Properties

• CAS Number: 35212-22-7
• MW: 280.32
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₆O₃
• SMILES: O=C1C(C2=CC=CC=C2)=COC3=CC(OC(C)C)=CC=C13
• Target: advanced glycation end products
• Solubility: Ethanol: 2 mg/mL (7.13 mM); DMSO: 56 mg/mL (199.77 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Osteofix

Quick Database Links

Gene Symbol

advanced glycation end products