Ipratropium Bromide

SKU: orb1225624

Description

Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 22254-24-6
• MW: 412.37
• Purity: >98% (HPLC)
• Formula: C₂₀H₃₀BrNO₃
• SMILES: CC([N+]1(C)C2CC(OC(C(C3=CC=CC=C3)CO)=O)CC1CC2)C.[Br-]
• Target: AChR
• Solubility: DMSO:83 mg/mL (201.27 mM); Ethanol:83 mg/mL (201.27 mM); Water:83 mg/mL (201.27 mM)

Bioactivity

• In Vivo:
  Animal model: Guinea-pigs of the Dunkin Hartley strain. Dosage: 0.1-1 μg/kg. Administration: Intravenous injection; single dose. Result: Resulted little blocking effect on post-junctional muscarinic receptors at 0.3 μg/kg, and inhibited ACh-induced bronchoconstriction at 0.5 μg/kg. Animal model: Male Sprague-Dawley rats (300-350 g). Dosage: 0.04 mg/20 mL and 0.20 mg/20 mL. Administration: Inhalation; atomization rate of 30 mL/30 min; 30 min. Result: Had no significant effects on any parameters recorded in healthy rats but exerted a protective effect against the inflammatory reaction elicited by cadmium.
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• In Vitro:
  Cell Viability Assay Cell line: Adult Rat Cardiac Myocyte. Concentration: 0.001 nM-0.1 mM Incubation time: 2 h in dark; prior to 4 h hypoxia. Result: Resulted cell viability in a dose-dependent manner, with the inhibition rate of 52.7% at 0.1 mM dose.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ipratropium Bromide

Quick Database Links

Gene Symbol

AChR