Indophagolin

SKU: orb1298503

Description

Indophagolin

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1207660-00-1
• MW: 523.75
• Purity: 99.76%
• Formula: C₁₉H₁₅BrClF₃N₂O₃S
• SMILES: FC(F)(F)c1cc(NS(=O)(=O)c2cc3N(CCc3cc2Br)C(=O)C2CC2)ccc1Cl
• Target: Autophagy,5-HT Receptor,P2X Receptor
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (3.82 mM);DMSO:25 mg/mL (47.73 mM)

Bioactivity

• Target IC50:
  P2X1:2.40μM|5-HT6 receptor:1.0 μM|P2X3:3.49 μM|P2Y6:15.4 μM|P2X4:2.71μM|Autophagy:140 nM|P2Y11:3.4 μM
• In Vitro:
  Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells and antagonizes Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). It also exhibits a strong antagonistic effect on the serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on the 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7 receptors.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

indoline-based, Indophagolin, inhibit, P2X Receptor, P2XRs, P2XReceptor, P2X1, P2X3, P2X4, membrane-bound, Inhibitor, formation, autophagy, Autophagy, autophagosome, 5-hydroxytryptamine Receptor, 5HTReceptor, 5HT Receptor, 5-HT Receptor, class, Serotonin Receptor

Compound Identifiers

PubChem CID

46504926