IKZF1 (M) Antibody, Rabbit Polyclonal

SKU: orb67129

Description

Rabbit polyclonal to IKZF1.Ikaros family zinc finger protein 1 (IKZF1) is a transcription factor that belongs to the family of zincfingerDNA binding proteins associated with chromatin remodeling. The expression of IKZF1 isrestricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator oflymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoformshave been described for this gene. All isoforms share a common C-terminal domain, which containstwo zinc finger motifs required for hetero-or homodimerization and for interactions with other proteins.The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and thenuclear localization signal, resulting in members with and without DNA-binding properties. Only a fewisoforms display high affinity binding to a specific core DNA sequence element in the promoters oftarget genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought tofunction as dominant negative factors. Overexpression of some dominant-negative isoforms havebeen associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Research Area

Epigenetics & Chromatin

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: middle region of human IKZF1
• Molecular Weight: 58
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-IKZF1 antibody,anti-DNAbinding protein Ikaros antibody,anti-Ikaros family zinc finger protein 1 antibody,anti-Lymphoid transcription factor LyF1 antibody,anti- IK1 antibody,anti-IKAROS antibody,anti-LYF1 antibody,anti-ZNFN1A1 antibody

Western blot analysis of total cell extracts from human Hela using IKZF1 antibody

Quick Database Links

UniProt

Q13422