Icenticaftor

SKU: orb1940188

Description

Icenticaftor is an orally active potentiator of CFTR channel.

Key Properties

• CAS Number: 1334546-77-8
• MW: 361.244
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₃F₆N₃O₃
• SMILES: COc1nc(C(=O)NC[C@](C)(O)C(F)(F)F)c(N)cc1C(F)(F)F
• Target: CFTR
• Solubility: In Vitro: DMSO : 150 mg/mL (415.24 mM)

Bioactivity

• In Vivo:
  In Sprague-Dawley rats, the pharmacokinetic profile of Icenticaftor isestablished. After oral administration at a dose of 3 mg/kg, the oral bioavailability is 90%, and AUClast is 20 635 nmol/L h.
• In Vitro:
  Icenticaftor (QBW251), an orally bioavailable small molecule CFTR potentiator, can restore CFTR function in specific CFTR genotypes as well as wild-type CFTR.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

QBW251

Quick Database Links

Gene Symbol

CFTR