Icatibant Acetate

SKU: orb1305988

Description

Icatibant Acetate

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 138614-30-9
• MW: 1364.57
• Purity: 99.68%
• Formula: C₆₁H₉₃N₁₉O₁₅S
• SMILES: CC(O)=O.[H][C@]12C[C@H](N(C(=O)[C@H]3Cc4ccccc4CN3C(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](N)CCCNC(N)=N)[C@@]1([H])CCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
• Target: Bradykinin Receptor
• Solubility: H2O:100 mg/mL (73.28 mM);DMSO:122.5 mg/mL (89.77 mM)

Bioactivity

• Target IC50:
  Bradykinin B2:0.798 nM(ki)|Bradykinin B2:1.07 nM
• In Vivo:
  Icatibant treatment exhibits efficacy in bradykinin-mediated angioedema attacks, and rapidly relieves symptom.
• In Vitro:
  Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, leading to a longer half-life than bradykinin which it antagonize.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

ulcerative, inhibit, Icatibant, Icatibant Acetate, Inhibitor, HOE 140, HOE140, HOE-140, angiotensin, bradykinin B2, bradykinin B2 receptor, Bradykinin Receptor, BradykininReceptor, colitis

Compound Identifiers

PubChem CID

6918172