Icatibant Acetate

SKU: orb1218867

Description

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 138614-30-9
• MW: 1364.57
• Purity: >98% (HPLC)
• Formula: C₆₁H₉₃N₁₉O₁₅S
• SMILES: CC(=O)O.N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3cccs3)C(=O)N[C@@H](CO)C(=O)N4Cc5ccccc5C[C@@H]4C(=O)N6[C@H]7CCCC[C@H]7C[C@H]6C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
• Target: Bradykinin Receptor
• Solubility: DMSO:100 mg/mL (73.28 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Female mice of the CBA/J (H-2k) strain. Dosage: 0.06, 0.3, or 1.5 mg/kg. Administration: Subcutaneous administration twice daily. Result: The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage, showing a significant preventive effect on shortening.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bradykinin Receptor