Histone Acetyltransferase Inhibitor II

SKU: orb1309573

Description

Histone Acetyltransferase Inhibitor II is a cell-permeable, selective p300 HAT inhibitor (IC50 = 5 µM). It effectively reduces acetylation in mammalian cells and is a valuable chemical probe for studying epigenetic regulation in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 932749-62-7
• MW: 464.15
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₁₆Br₂O₃
• SMILES: Oc1ccc(\C=C2/CCC\C(=C/c3ccc(O)c(Br)c3)C2=O)cc1Br
• Target: Histone Acetyltransferase,Epigenetic Reader Domain
• Solubility: DMSO:30 mg/mL (64.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.31 mM)

Bioactivity

• Target IC50:
  p300:5 μM
• In Vitro:
  Histone Acetyltransferase Inhibitor II (compound 2c) was the most active inhibitor, also showing high specificity for p300 as compared to other histone acetyltransferases. Most notably, 2c showed anti-acetylase activity in mammalian cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p300, inhibit, Inhibitor, HAT, HATs, HeLa, histones, HistoneAcetyltransferase, Histone Acetyltransferase, Histone Acetyltransferase Inhibitor II, EpigeneticReaderDomain, Epigenetic Reader Domain, H2B-EYFP, anti-acetylase, acetylation

Compound Identifiers

PubChem CID

16203606