Histone Acetyltransferase Inhibitor II

SKU: orb1220087

Description

Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells. Histone Acetyltransferase Inhibitor II (compound 2c) was the most active inhibitor, also showing high specificity for p300 as compared to other histone acetyltransferases. Most notably, 2c showed anti-acetylase activity in mammalian cells.

Research Area

Epigenetics & Chromatin; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 932749-62-7
• MW: 464.15
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₆Br₂O₃
• SMILES: C1CC(=CC2=CC(=C(C=C2)O)Br)C(=O)C(=CC3=CC(=C(C=C3)O)Br)C1
• Target: Epigenetic Reader Domain
• Solubility: DMSO:30 mg/mL (64.63 mM)

Bioactivity

• In Vitro:
  Histone Acetyltransferase Inhibitor II (20-40 μM) decreases the levels of H3 acetylation in HeLa-H2B-EYFP cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Epigenetic Reader Domain