Hexamethylene bisacetamide

SKU: orb1299435

Description

Hexamethylene bisacetamide

Research Area

Cell Biology, Epigenetics & Chromatin, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3073-59-4
• MW: 200.28
• Purity: 98.00% (May vary between batches)
• Formula: C₁₀H₂₀N₂O₂
• SMILES: CC(=O)NCCCCCCNC(C)=O
• Target: Epigenetic Reader Domain,Others,Akt,Bcl-2 Family,MDM-2/p53,p38 MAPK,Gamma-secretase,NF-κB,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.99 mM);DMSO:25 mg/mL (124.83 mM)

Bioactivity

• In Vitro:
  As expected of a BET inhibitor, HMBA displaced BET proteins from chromatin, caused massive transcriptional changes, and triggered cell-cycle arrest and apoptosis in Myc-induced B-cell lymphoma cells. Furthermore, HMBA exerted anticancer effects in vivo in mouse models of Myc-driven B-cell lymphoma.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, EpigeneticReaderDomain, Epigenetic Reader Domain, HMBA, Hexamethylene bisacetamide, BET

Compound Identifiers

PubChem CID

3616