HDAC6 degrader-3

SKU: orb1982406

Description

HDAC6 degrader-3 is a potent and selective degrader of HDAC6, achieving degradation via ternary complex formation and the ubiquitin-proteasome system with a DC50 of 19.4 nM. It induces strong α-tubulin hyperacetylation and is a valuable chemical probe for studying HDAC6 biology in cellular and in vivo models of cancer and neurodegenerative diseases.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2785404-83-1
• MW: 883.8
• Formula: C₄₁H₄₁F₄N₇O₁₁
• SMILES: C(C(O)=O)(F)(F)F.O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCC(NC=4C=C5C(=CC4)N(CC6=C(F)C=C(C(NO)=O)C=C6)C(C)=N5)=O)=O
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166642469