PROTAC HDAC6 degrader 3

SKU: orb2945794

Description

PROTAC HDAC6 degrader 3 (Compound 4) is a bifunctional molecule that selectively targets and degrades HDAC6, exhibiting an IC50 of 686 nM and a DC50 of 171 nM. It induces α-tubulin acetylation and is a valuable chemical tool for studying HDAC6 biology in cellular and in vivo models of cancer and neurodegenerative diseases.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• MW: 963.06
• Formula: C₄₆H₅₆F₂N₁₀O₉S
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCC(=O)NCC4=CC=CC(=C4)CNC5=NC=C(C=N5)C6=NN=C(O6)C(F)F)O
• Target: PROTACs,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677101