Groenlandicine

SKU: orb1297594

Description

Groenlandicine is a protoberberine alkaloid with potential as an anti-Alzheimer's agent, demonstrating inhibition of cholinesterases, beta-amyloid formation, and oxidative stress. It also acts as a topoisomerase I-mediated DNA cleaving agent and a moderate aldose reductase inhibitor (IC50 = 154.2 µM against HRAR), supporting research in neurodegeneration and enzymology.

Research Area

Cell Biology, Immunology & Inflammation, Molecular Biology, Neuroscience

Key Properties

• CAS Number: 38691-95-1
• MW: 322.34
• Purity: 99.77%
• Formula: C₁₉H₁₆NO₄
• SMILES: O(C)C=1C=C2C=3[N+](=CC4=C(C3)C=CC5=C4OCO5)CCC2=CC1O
• Target: Beta-Secretase,ROS,Topoisomerase,Cholinesterase (ChE),Apoptosis
• Solubility: DMSO:1.83 mg/mL (5.68 mM)

Bioactivity

• In Vitro:
  Isolated alkaloids from Coptis chinensis Franch. The compounds were identified as berberine, columbamine, Groenlandicine, jatrorrhizine, magnoflorine, corydaldine and ferulic acid methylester. Then measured their bitter degree based on the electronic tongue and evaluated the antibacterial. The results based on the Electronic Tongue showed that berberine, columbamine, Groenlandicine and jatrorrhizine have higher bitter degree than magnoflorine and corydaldine. And they also appeared better antibacterial activity on E. coli and S. aureus. The correlation coefficients between bitter degree and the two bacteria antibacterial activity were 0.983 and 0.911

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AChR, BChE, inhibit, Groenlandicine, Inhibitor, Topoisomerase, topoisomerase I, ROS

Compound Identifiers

PubChem CID

3084708