GLPG2938

SKU: orb1218450

Description

GLPG2938 is a potent and selective antagonist of S1P2.

Key Properties

• CAS Number: 2130996-00-6
• MW: 503.4
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₉F₆N₇O₂
• SMILES: CCOc1cc(NC(NCc2nnc(-c3cn(C)nc3C(F)(F)F)c(C)c2)=O)cc(C(F)(F)F)n1
• Target: S1P Receptor
• Solubility: In Vitro: DMSO : 100 mg/mL (198.65 mM)

Bioactivity

• In Vivo:
  GLPG2938 (1~10 mg/kg; p.o.) displays a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score. GLPG2938 shows good pharmacokinetics, with long half-life, low clearance, and good bioavailability in all species, especially in dogs. Animal model: Male C57BL/6 mice. Dosage: 1~10 mg/kg. Administration: p.o. Result: Displayed a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score. .
• In Vitro:
  GLPG2938 (0.5~5 μM; HPF cells) significantly prevents the S1P-mediated contraction at all tested concentrations.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea

Quick Database Links

Gene Symbol

S1P Receptor