Gcase activator 2

SKU: orb2566189

Description

Gcase activator 2 is a small molecule that promotes β-glucocerebrosidase (GCase) dimerization and activity at both ER and lysosomal pH, enhancing lysosomal substrate clearance. It is a research tool for investigating GCase biology and its therapeutic potential in Parkinson's and Gaucher disease models, both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2759897-35-1
• MW: 364.44
• Purity: 99.51%
• Formula: C₂₁H₂₄N₄O₂
• SMILES: O=C(N1CCC(C2=CC=3N=C(C=NC3N2C)C4=CC=C(OC)C=C4)CC1)C
• Target: glycosidase,Glucosidase,Glucokinase
• Solubility: DMSO:80 mg/mL (219.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.05 mM)

Bioactivity

• In Vitro:
  Gcase activator 2 exhibits a low metabolic clearance rate in both humans and mice, with CL values of 10 and 12 μL/min/mg, respectively .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155289224