Garetosmab Antibody

SKU: orb1980428

Description

Garetosmab (REGN 2477) is a human IgG4 monoclonal antibody that selectively inhibits activin A. It is utilized in research for fibrodysplasia ossificans progressiva (FOP) and explored in oncology, with studies conducted in both in vitro and in vivo experimental models.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2097125-54-5
• MW: 146 kDa
• Purity: > 95%
• Target: TGF-beta/Smad

Bioactivity

• In Vitro:
  Specifically binding to and blocking signaling of activin proteins containing the inhibin βα subunit (activins A, AB, and AC), garetosmab (REGN 2477) has high affinity and specificity for activins A, AB, and AC in vitro. It does not bind or functionally inhibit other TGF-β family ligands that share the same activin receptor pathways, including activin B, inhibin A, BMP-2, BMP6, BMP9, BMP10, GDF8, and GDF11.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Garetosmab, TGFb, TGFβ, TGFbeta/Smad, TGF-beta, TGFbeta, TGF-b/Smad, TGF-β Receptor, TGF-β/Smad, Smad, REGN 2477, REGN2477, REGN-2477

Quick Database Links

Gene Symbol

TGF-beta/Smad