FT011

SKU: orb1299943

Description

FT011 is a direct anti-fibrotic small molecule that reduces cardiac remodeling and dysfunction in models of diabetic cardiomyopathy. It is a research tool for studying fibrosis in cardiovascular and metabolic disease research, with demonstrated efficacy in both in vivo and in vitro experimental systems.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1001288-58-9
• MW: 351.35
• Purity: 98.98%
• Formula: C₂₀H₁₇NO₅
• SMILES: COc1cc(\C=C\C(=O)Nc2ccccc2C(O)=O)ccc1OCC#C
• Target: MMP,Others
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.69 mM);DMSO:29 mg/mL (82.54 mM)

Bioactivity

• In Vivo:
  A direct anti-fibrotic agent, FT011, attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy.
• Animal Research:
  Homozygous Ren-2 rats were randomized to receive streptozotocin or vehicle then further randomized to FT011 (200 mg/kg/day) or vehicle treatment for 6 weeks. Prior to tissue collection, cardiac function was assessed via echocardiography and cardiac catheterization. Total collagen deposition and cardiomyocyte hypertrophy were assessed by picrosirius red and haematoxylin and eosin staining, respectively. Macrophage interstitial infiltration and type I and III collagen were quantitated by immunostaining.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, FT 011, FT011, FT-011

Compound Identifiers

PubChem CID

23648966