FT-011

SKU: orb1227185

Description

A novel anti-fibrotic agent that prevents TGF-beta-stimulated production of collagen in cultured renal mesangial cells (55-70% inhibition at 30 uM); inhibits both TGF-β1 and PDGF-BB induced collagen production as well as PDGF-BB-mediated mesangial proliferation, attenuates the decline in GFR, proteinuria and glomerulosclerosis in a robust model of non-diabetic kidney disease; attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy.(In Vivo):FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats.

Key Properties

• CAS Number: 1001288-58-9
• MW: 351.3527
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₇NO₅
• SMILES: O=C(O)C1=CC=CC=C1NC(/C=C/C2=CC=C(OCC#C)C(OC)=C2)=O
• Target: TGFBR
• Solubility: DMSO: ≥ 29 mg/mL

Bioactivity

• In Vivo:
  FT011 (100 mg/kg b. i. d. , p.o. , for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats. Animal model: Seventy male Sprague Dawley (SD) rats (weighing 200-250 g). Dosage: 100 mg/kg. Administration: B. I. D. , p.o. on day 7 after surgery, for 4 weeks. Result: Increased ejection fraction, fraction shortening and preload recruitable stroke work.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FT011 | SHP-627

Quick Database Links

Gene Symbol

TGFBR