Fluorometholone Acetate

SKU: orb1300711

Description

Fluorometholone Acetate (Oxylone acetate) is a synthetic glucocorticoid used in ophthalmic research to model and treat inflammatory eye conditions. It is applied in both in vitro assays and in vivo animal studies to investigate corticosteroid mechanisms, anti-inflammatory efficacy, and ocular pharmacokinetics.

Research Area

Metabolism Research

Key Properties

• CAS Number: 3801-06-7
• MW: 418.50
• Purity: 99.77%
• Formula: C₂₄H₃₁FO₅
• SMILES: [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
• Target: Glucocorticoid Receptor,Carbonic Anhydrase
• Solubility: DMSO:84 mg/mL (200.72 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.89 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  CA II (human):17.5 μM (IC50)|CA II (human):9.98 μM (Ki)|CA I (human):2.18 μM (IC50)|CA I (human):1.044 μM (Ki)
• In Vivo:
  Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use.
• In Vitro:
  Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-inflammatory, Carbonate dehydratase, Carbonic Anhydrase, CarbonicAnhydrase, Cornea, corticosteroid, hCA-I, hCA-II, Eflone, Fluorometholone, Fluorometholone Acetate, GlucocorticoidReceptor, glucocorticoid, Glucocorticoid Receptor, Flarex, NSC47438, NSC-47438, inhibit, Inhibitor, NSC 47438, Oxylone Acetate, Oxylone acetate

Compound Identifiers

PubChem CID

240767