Flufenamic acid

SKU: orb1310228

Description

Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in research on musculoskeletal disorders and serves as a tool compound in vitro and in vivo to study ion channel modulation and inflammatory pathways.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 530-78-9
• MW: 281.23
• Purity: 98.68% (May vary between batches)
• Formula: C₁₄H₁₀F₃NO₂
• SMILES: OC(=O)C1=C(NC2=CC(=CC=C2)C(F)(F)F)C=CC=C1
• Target: Chloride channel,AMPK,Potassium Channel,Calcium Channel,COX,Parasite
• Solubility: DMSO:250 mg/mL (888.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.11 mM);Ethanol:28.1 mg/mL (99.92 mM)

Bioactivity

• In Vivo:
  Under peak amyloid fibril formation conditions (pH 4.4), Flufenamic acid binds to wild-type transthyretin (KD1=30 nM, KD2=255 nM), V30M transthyretin (KD1=41 nM, KD2=320 nM), and L55P transthyretin (KD1=74 nM, KD2=682 nM) with high affinity and negative cooperativity (pH value 7.6), fully inhibiting fibril formation at a concentration of 10.8 μM. In Xenopus oocytes, Flufenamic acid reversibly suppresses ICl(Ca) in a dose-dependent manner, with an IC50 of 28 mM, without affecting the shape of the current-voltage curve in response to depolarizing voltage. Flufenamic acid inhibits the calcium-activated non-selective cation channels in the basolateral membrane of rat pancreatic exocrine cells activated by an inward-outward patch with an IC50 of 10 μM. The compound also inhibits currents activated by intracellular ADP-ribose in recombinant human TRPM2 (hTRPM2) channels and the CRI-G1 rat insulinoma cell line. Additionally, it reversibly inhibits (IC50=13.8 μM) DAP and phase discharge in rat suprachiasmatic neurons with similar kinetics, without significantly affecting membrane potential, spike threshold, or input resistance (P > 0.05), nor does it significantly affect the frequency and amplitude of spontaneous synaptic potentials.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nichisedan, Parasite, KcsA, inhibit, Flufenamic acid, Inhibitor, Cyclooxygenase, Chloride Channel, Chloride channel, Chloridechannel, Cl? Channels, CalciumChannel, COX, AMPK, Arlef, Calcium Channel, Ca2+ channels, Ca channels, Achless, AMP-activated protein kinase, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

3371