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EPZ6438

SKU: orb1226354

Description

EPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.

Images & Validation

Key Properties

CAS Number1403254-99-8
MW572.74
Purity>98% (HPLC)
FormulaC34H44N4O4
SMILESO=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
TargetHMTase
SolubilityDMSO: 9 mg/mL (15.71 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Tazemetostat

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Protocol Information

EPZ6438 (orb1226354)

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Available Sizes

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5 mg
$ 100.00
10 mg
$ 130.00
50 mg
$ 160.00
100 mg
$ 240.00
200 mg
$ 340.00
500 mg
$ 610.00