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EMI1

SKU: orb1689021

Description

EMI1

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number35773-42-3
MW334.37
Purity99.96%
FormulaC20H18N2O3
SMILESCCN(CC)C1=CC2=C(C=C1)C=C(C1=NC3=C(O1)C=CC=C3)C(=O)O2
TargetEGFR
SolubilityDMSO:1.8 mg/mL (5.38 mM)

Bioactivity

In Vitro
EMI1 (1 nM-100μM) significantly increase the caspase 3/7 activity and inhibits the viability and of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells. EMI1 inhibits growth of PC9 EGFR ex19del/T790M/C797S organoid with the EC50 of 131 nM. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

EGFR

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Key Properties

No computed properties available.

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Protocol Information

EMI1 (orb1689021)

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% DMSO +
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% Tween 80 +
%

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5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 160.00
50 mg
$ 240.00
100 mg
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200 mg
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