Elubrixin

SKU: orb1309710

Description

Elubrixin (SB-656933) is a potent, selective, and orally active antagonist of CXCR2/IL-8 receptors. It inhibits neutrophil activation, demonstrated by blocking CD11b upregulation and shape change in vitro, and is used in research models of inflammatory bowel disease and airway inflammation.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 688763-64-6
• MW: 463.31
• Purity: 98.65% (May vary between batches)
• Formula: C₁₇H₁₇Cl₂FN₄O₄S
• SMILES: S(=O)(=O)(C1=C(O)C(NC(NC2=C(Cl)C(F)=CC=C2)=O)=CC=C1Cl)N3CCNCC3
• Target: Interleukin,IL Receptor,CXCR
• Solubility: DMSO:10 mg/mL (21.58 mM)

Bioactivity

• In Vitro:
  Elubrixin inhibits neutrophil CD11b upregulation with an IC50 of 260.7 nM and shapes change with an IC50 of 310.5 nM. Elubrixin has an inhibitory effect on neutrophils in a dose-dependent manner.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SB 656933, SB656933, SB-656933, inhibit, IL-8, ILReceptor, Inhibitor, neutrophil-mediated, Elubrixin, IL Receptor, Interleukin Related, airway, anti-inflammatory, bowel, CD11b, CXC chemokine receptors, CXCR2, CXCR

Compound Identifiers

PubChem CID

10479502