Elubrixin tosylate

SKU: orb2655590

Description

Elubrixin (SB-656933) is a potent, selective, competitive and reversible CXCR2 antagonist; inhibits CXCL1-induced CD11b up-regulation on PMNs in an in vitro whole blood assay and to be active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.Fibrosis Phase 2 Discontinued.

Key Properties

• CAS Number: 960495-43-6
• MW: 635.503
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₅Cl₂FN₄O₇S₂
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1CN(CCN1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl
• Target: Chemokine Receptor
• Solubility: In Vitro: DMSO : 125 mg/mL (196.69 mM)

Bioactivity

• In Vitro:
  Elubrixin has an inhibitory effect on neutrophils in a dose-dependent fashion.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SB-656933

Quick Database Links

Gene Symbol

Chemokine Receptor