Duocarmycin Antibody

SKU: orb3002161

Description

Duocarmycin, a DNA minor groove-binding alkylating agent, acts as a payload in antibody-drug conjugates (ADCs) by selectively targeting AT-rich regions of DNA. It forms covalent bonds with the N3 position of adenine, inducing strand breaks and apoptosis through S-phase cell cycle arrest . This mechanism bypasses multidrug resistance pathways, making it potent against aggressive tumors.

Images & Validation

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Reactivity	Rabbit

Key Properties

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Clonality	Monoclonal
Isotype	Rabbit IgG \| Rabbit Kappa
Target	Duocarmycin
Source/Expression System	HEK293
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Form/Appearance	Powder
Buffer/Preservatives	PBS, pH 7.4
Disclaimer	For research use only

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Gene Symbol

Duocarmycin

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