Doxapram

SKU: orb1704832

Description

Doxapram is a respiratory stimulant that acts by inhibiting TASK-1 and TASK-3 potassium channels. It is used in research models of ventilatory control, including studies of apnea of prematurity and COPD-related respiratory depression, in both in vivo and in vitro experimental settings.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 309-29-5
• MW: 378.51
• Purity: 99.42%
• Formula: C₂₄H₃₀N₂O₂
• SMILES: O=C1N(CC)CC(CCN2CCOCC2)C1(C=3C=CC=CC3)C=4C=CC=CC4
• Target: Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.28 mM);Ethanol:50 mg/mL (132.1 mM);DMSO:50 mg/mL (132.1 mM)

Bioactivity

• Target IC50:
  TASK1/TASK3:9 μM (EC50)|K+ currents recorded (type I cells):13 mM|TASK1:410 nM (EC50)|TASK3:37 μM (EC50)
• In Vitro:
  Doxapram inhibits TASK-1 (EC50=410 nM), TASK-3 (EC50=37 μM), TASK-1/TASK-3 (EC50=9 μM) heterodimeric channel function. Doxapram also evoked 3H overflow in a concentration dependent manner, and Doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 mM). Doxapram (1-100 mM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50=13 mM). Doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dopram, Doxapram, Potassium Channel, PotassiumChannel, TASK-1, TASK-3

Compound Identifiers

PubChem CID

3156