Desvenlafaxine

SKU: orb1223609

Description

Desvenlafaxine (O-desmethylvenlafaxine) the major active metabolite of venlafaxine, is an antidepressant from the serotonin-norepinephrine reuptake inhibitor (SNRI class). Desvenlafaxine may be used to treat major depressive disorder and is being studied for use in the management of vasomotor symptoms in postmenopausal women. It is formulated as an extended release tablet. FDA approved in 2008. (In Vitro):Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Desvenlafaxine also induces CYP3A4, which could impact the metabolism of drugs metabolized via this enzyme.(In Vivo):Desvenlafaxine (30 mg/kg, orally) significantly increases extracellular NE levels but had no effect on DA levels using microdialysis.

Key Properties

• CAS Number: 93413-62-8
• MW: 263.38
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₅NO₂
• SMILES: CN(C)CC(C1=CC=C(O)C=C1)C1(O)CCCCC1
• Target: 5-HT Receptor
• Solubility: Ethanol: 3 mg/mL (11.39 mM); DMSO: 37 mg/mL (140.48 mM)

Bioactivity

• In Vivo:
  Desvenlafaxine (30 mg/kg, orally) significantly increases extracellular NE levels but had no effect on DA levels using microdialysis. Animal model: Male rats. Dosage: 30 mg/kg. Administration: Orally. Result: Significantly increased extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis.
• In Vitro:
  Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Desvenlafaxine also induces CYP3A4, which could impact the metabolism of drugs metabolized via this enzyme.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Desvenlafaxine | DVS 233 | MDD-XR

Quick Database Links

Gene Symbol

5-HT Receptor