Cyclothiazide

SKU: orb1302746

Description

Cyclothiazide is a benzothiadiazide compound that acts as a potent and selective positive allosteric modulator of AMPA receptors. It inhibits receptor desensitization, enhancing glutamate-evoked currents (EC50 = 3.8 µM), and is widely used in neuroscience research to study synaptic transmission, plasticity, and excitatory signaling in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2259-96-3
• MW: 389.88
• Purity: >99.99% (May vary between batches)
• Formula: C₁₄H₁₆ClN₃O₄S₂
• SMILES: NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C2CC3CC2C=C3)cc1Cl
• Target: GABA Receptor,GluR,iGluR
• Solubility: DMSO:127.5 mg/mL (327.02 mM);Ethanol:25 mM

Bioactivity

• Target IC50:
  AMPA:EC50 = 3.8 M

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclothiazide, current potentiation, AMPA receptor desensitization, AMPA, neurones, Ionotropic glutamate receptors, Inhibitor, inhibit, iGluR, positive allosteric modulator

Compound Identifiers

PubChem CID

2910