Cyclothiazide

SKU: orb1222496

Description

Cyclothiazide (Anhydron, Acquirel, Doburil, Fluidil, Renazide, Tensodiural, Valmiran) is a benzothiadiazide (thiazide) diuretic and antihypertensive that was originally introduced in the United States in 1963 by Eli Lilly and was subsequently also marketed in Europe and Japan. This agent is capable of inhibiting rapid desensitization of the ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors, thereby potentiating glutamate responses which may induce seizures activity. Cyclothiazide was also found to inhibit gamma-aminobutyric acid (GABA)-A receptors.

Key Properties

• CAS Number: 2259-96-3
• MW: 389.9
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₆ClN₃O₄S₂
• SMILES: NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C2CC3CC2C=C3)cc1Cl
• Target: LDL
• Solubility: In Vitro: DMSO : 125 mg/mL (320.61 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclothiazide | Anhydron | Renazide | Valmiran

Quick Database Links

Gene Symbol

LDL