Cyclo(RGDyK) trifluoroacetate

SKU: orb1300443

Description

Cyclo(RGDyK) trifluoroacetate is a selective αVβ3 integrin antagonist with an IC50 of 20 nM. This cyclic RGD peptide is widely used in vitro and in vivo to study angiogenesis, tumor metastasis, and osteoporosis by blocking integrin-mediated cell adhesion and signaling pathways.

Research Area

Signal Transduction

Key Properties

• CAS Number: 250612-42-1
• MW: 847.72
• Purity: 98.00% (May vary between batches)
• Formula: C₃₁H₄₃F₆N₉O₁₂
• SMILES: OC(C(F)(F)F)=O.NCCCC[C@@H]1NC([C@H](NC([C@@H](NC(CNC([C@@H](NC1=O)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC2=CC=C(C=C2)O)=O.OC(C(F)(F)F)=O
• Target: Integrin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (4.72 mM);DMSO:130 mg/mL (153.35 mM)

Bioactivity

• Target IC50:
  αvβ3 integrin:20 nM
• In Vivo:
  In apoE / mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery.
• In Vitro:
  Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM).

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclo(RGDyK), Cyclo(RGDyK) trifluoroacetate, Cyclo(RGDyK) Trifluoroacetate, Inhibitor, Integrin, inhibit, αVβ3 integrin

Compound Identifiers

PubChem CID

129896716