Cyclo(RGDyK) trifluoroacetate

SKU: orb1225519

Description

Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys) is a cyclic derivative of RGD, potent, selective αVβ3 integrin inhibitor with IC50 of 20 nM; a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including αvβ3.(In Vitro):Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM).

Key Properties

• CAS Number: 250612-42-1
• MW: 847.72
• Purity: >98% (HPLC)
• Formula: C₃₁H₄₃F₆N₉O₁₂
• SMILES: C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=C(C=C2)O)CC(=O)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
• Target: Integrin
• Solubility: DMSO: 94 mg/mL (110.9 mM)Water: 94 mg/mL (110.9 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vitro:
  Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5(IC50 = 4000 nM) and αIIbβ3 (IC50 = 3000 nM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclic Arg-Gly-Asp-D-Tyr-Lys

Quick Database Links

Gene Symbol

Integrin