Cycloleucine

SKU: orb1297971

Description

Cycloleucine is a competitive antagonist of the glycine site on the NMDA receptor (Ki = 600 µM) and an inhibitor of S-adenosyl-methionine-dependent methylation. Its cytostatic and anxiolytic-like properties make it a useful research tool for studying neurotransmission, epigenetics, and cancer biology in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 52-52-8
• MW: 129.16
• Purity: 99.90% (May vary between batches)
• Formula: C₆H₁₁NO₂
• SMILES: NC1(CCCC1)C(O)=O
• Target: iGluR,NMDAR
• Solubility: H2O:51.5 mg/mL (398.73 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Cycloleucine (0.5, 1.0, 2.0, 4 µg/µL; intracerebroventrically) increases time spent in open arms, open arm entries, and extreme arrivals in rats. In Semliki Forest virus strain A7(74) infected and control mice, Cycloleucine reduces thymus and spleen weights.
• In Vitro:
  Cytostatic (10 µg/mL) inhibits the viability of human KB and mouse L1210s leukemia cell lines. Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cycloleucine, cytostatic, ATP, anxiolytic, iGluR, Inhibitor, glycine, inhibit, Ionotropic glutamate receptors, methylations, NMDA receptor, NMDA, nucleic, transferase

Compound Identifiers

PubChem CID

2901