Cyclogalegenol

SKU: orb1220869

Description

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression.

Key Properties

• CAS Number: 78574-94-4
• MW: 490.72
• Purity: >98% (HPLC)
• Formula: C₃₀H₅₀O₅
• SMILES: [H][C@@]1([C@@H](O)C[C@@]2(C)[C@]3([H])C[C@H](O)[C@]4([H])[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O)C4(C)C)[C@@]1(C)CC[C@H](O1)C(C)(C)O
• Target: Epigenetic Reader Domain
• Solubility: DMSO:98 mg/mL (199.71 mM)

Bioactivity

• In Vivo:
  Cycloastragenol (5, 10, 20 mg/kg) is injected intraperitoneally at the onset of reperfusion, 12 h later and then twice daily for up to three days. Cycloastragenol dose-dependently reduces brain infarct volume, significantly ameliorated functional deficits, and prevents neuronal cell loss in middle cerebral artery occlusion (MCAO) mice. Cycloastragenol suppresses the mRNA expression of pro-inflammatory cytokines, including TNF-α and IL-1β, and inhibits the activation of microglia and astrocytes in the ischemic brain.
• In Vitro:
  Cycloastragenol (0.03-3 μM; 24-72 hours) promotes viability, osteoblastic differentiation, and mineralization in MC3T3-E1 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Astramembrangenin

Quick Database Links

Gene Symbol

Epigenetic Reader Domain