Cyclin E1 Antibody / CCNE1

• Catalog Number: orb640019
• Category: Antibodies
• Description: Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: CCNE1/2587
• Tested applications: ELISA
• Reactivity: Human
• Isotype: Mouse IgG
• Immunogen: A recombinant human partial protein (amino acids 10-176) was used as the immunogen for this Cyclin E1 antibody.
• Antibody Type: Primary Antibody
• Dilution range: ELISA (order BSA-free format for coating)
• Purity: Protein G affinity chromatography
• Conjugation: Unconjugated
• Formula: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Hazard Information: This Cyclin E1 antibody is available for research use only.
• UniProt ID: P24864
• Storage: Store the Cyclin E1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
• Buffer/Preservatives: 0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
• Note: For research use only
• Application notes: Optimal dilution of the antibody should be determined by the researcher.
• Expiration Date: 12 months from date of receipt.

SDS-PAGE analysis of purified, BSA-free Cyclin E1 antibody (clone CCNE1/2587) as confirmation of integrity and purity.