Cyclin E1 Antibody / CCNE1

• Catalog Number: orb640019
• Category: Antibodies
• Description: Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
• Clonality: Monoclonal
• Species/Host: Mouse
• Isotype: Mouse IgG
• Conjugation: Unconjugated
• Reactivity: Human
• Immunogen: A recombinant human partial protein (amino acids 10-176) was used as the immunogen for this Cyclin E1 antibody.
• UniProt ID: P24864
• Tested applications: ELISA
• Dilution range: ELISA (order BSA-free format for coating)
• Application notes: Optimal dilution of the antibody should be determined by the researcher.
• Antibody Type: Primary Antibody
• Clone Number: CCNE1/2587
• Formula: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Hazard Information: This Cyclin E1 antibody is available for research use only.
• Note: For research use only

SDS-PAGE analysis of purified, BSA-free Cyclin E1 antibody (clone CCNE1/2587) as confirmation of integrity and purity.