CXCR2-IN-2

SKU: orb1693324

Description

CXCR2-IN-2 is a potent, selective, and brain-penetrant CXCR2 antagonist with oral bioavailability. It demonstrates high selectivity over CXCR1 and other chemokine receptors and effectively inhibits Gro-α-induced CD11b expression in human whole blood. This compound is a valuable tool for researching CXCR2's role in neuroinflammation, COPD, and cancer in both in vitro and in vivo models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1838123-21-9
• MW: 414.9
• Formula: C₁₈H₂₃ClN₂O₅S
• SMILES: S(=O)(=O)(C1=C(O)C(NC(N[C@H]2C(C)=CCC2)=O)=CC=C1Cl)[C@@]3(C)CCOC3
• Target: CXCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

100951623