(R,R)-CXCR2-IN-2

SKU: orb1693733

Description

(R,R)-CXCR2-IN-2 is a brain-penetrant CXCR2 antagonist, a diastereoisomer of compound 68. It demonstrates potent antagonistic activity with a pIC50 of 9.0 in the Tango assay and 6.8 in a human whole blood CD11b expression assay. This compound is a valuable research tool for investigating CXCR2-mediated neuroinflammation in both in vitro and in vivo models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1838123-22-0
• MW: 414.9
• Formula: C₁₈H₂₃ClN₂O₅S
• SMILES: CC1=CCC[C@H]1NC(=O)Nc1ccc(Cl)c(c1O)S(=O)(=O)[C@]1(C)CCOC1
• Target: Others,CXCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118540525