CPCCOEt

SKU: orb1704593

Description

CPCCOEt is a reversible, non-competitive, and selective mGluR1b antagonist with low binding affinity. It is utilized in neuroscience research to investigate metabotropic glutamate receptor function in both cellular assays and animal models of neurological disorders.

Research Area

Neuroscience

Key Properties

• CAS Number: 179067-99-3
• MW: 247.25
• Purity: 99.87% (May vary between batches)
• Formula: C₁₃H₁₃NO₄
• SMILES: CCOC(=O)C12CC1\C(=N/O)c1ccccc1O2
• Target: GluR
• Solubility: DMSO:90 mg/mL (364 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (13.35 mM)

Bioactivity

• Target IC50:
  mGluR1b (human):6.5 μM
• In Vivo:
  Whole-cell voltage recording from Purkinje cells in slices of rat cerebellum showed that CPCCOEt enhanced the climbing fiber response at concentrations of blocking the mGlu1 receptor(100 μM).
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• In Vitro:
  CPCCOEt selectively inhibited glutamate-induced increases in intracellular calcium at human mGluR1b (hmGluR1b) with an apparent IC50 of 6.5 μM while having no agonist or antagonist activity at hmGluR2, -4a, -5a, -7b, and -8a up to 100 μM. In addition, introduction of Thr815 and Ala818 at the homologous positions of hmGluR5a conferred complete inhibition by CPCCOEt (IC50 = 6.6 μM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CPCCOEt, mGluR1

Compound Identifiers

PubChem CID

6278000