CP 465022

SKU: orb2901498

Description

CP-465022 is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC50 of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes.

Key Properties

• CAS Number: 199655-36-2
• MW: 462.95
• Purity: >98% (HPLC)
• Formula: C₂₆H₂₄ClFN₄O
• SMILES: CCN(CC)Cc1cccc(C=Cc2nc3ccc(F)cc3c(=O)n2-c2ccccc2Cl)n1
• Target: iGluR
• Solubility: In Vitro: DMSO : 50 mg/mL (108.00 mM; Ultrasonic )

Bioactivity

• In Vitro:
  CP-465022 1 μM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%. CP-465, 022 at 10 μM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons. CP-465022 1 μM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons. CP-465022 (100 nM -10 μM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465, 022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 μM CP-465, 022 nearly complete inhibits this time frame (99.3%).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

iGluR