CP 465022

SKU: orb1705018

Description

CP 465022 hydrochloride is a selective, noncompetitive AMPA receptor antagonist with an IC50 of 25 nM against kainate-induced currents in rat cortical neurons. This compound exhibits anticonvulsant properties and is utilized in neuroscience research to study excitatory neurotransmission, synaptic plasticity, and seizure mechanisms in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 199655-36-2
• MW: 462.95
• Purity: 99.05%
• Formula: C₂₆H₂₄ClFN₄O
• SMILES: CCN(CC)Cc1cccc(C=Cc2nc3ccc(F)cc3c(=O)n2-c2ccccc2Cl)n1
• Target: iGluR
• Solubility: DMSO:4.63 mg/mL (10 mM)

Bioactivity

• Target IC50:
  Kainate-induced response:25 nM (rat cortical neurons)
• In Vitro:
  CP 465022 hydrochloride 1 µM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 µM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons. CP 465022 hydrochloride (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC50 of 25 nM and essentially complete inhibition at 3.2 µM. CP 465022 hydrochloride 1 µM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons. CP 465022 hydrochloride (100 nM -10 µM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 µM CP-465,022 nearly complete inhibits this time frame (99.3%).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPAR, CP 465022, CP 465022 hydrochloride, CP465022, CP-465022

Compound Identifiers

PubChem CID

53902824