Concizumab Antibody

SKU: orb1944800

Description

Concizumab is an IgG4 monoclonal antibody targeting the KPI2 domain of TFPI, inhibiting its interaction with FXa to enhance thrombin generation. It is applied in hemophilia research, with studies demonstrating its prophylactic and therapeutic potential in both in vitro coagulation assays and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1312299-39-0
• MW: 145.76 kDa
• Purity: > 95%
• Target: Factor Xa,Others

Bioactivity

• In Vivo:
  In cynomolgus monkeys, Concizumab (i.v./s.c.) blocked the interaction between TFPI and FXa active site .
• In Vitro:
  In a concentration-dependent manner, Concizumab increases the peak value of thrombin .

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NN 7415, NN7415, NN-7415, mAb 2021, Concizumab

Quick Database Links

Gene Symbol

Factor Xa,Others