Cholic acid sodium

SKU: orb1302776

Description

Cholic acid sodium

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 361-09-1
• MW: 430.55
• Purity: 99.81% (May vary between batches)
• Formula: C₂₄H₃₉NaO₅
• SMILES: O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC([O-])=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C.[Na+]
• Target: HIV Protease,Endogenous Metabolite
• Solubility: H2O:62.5 mg/mL (145.16 mM);DMSO:50 mg/mL (116.13 mM)

Bioactivity

• In Vivo:
  Cholic acid (sodium cholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity. The same effects are observed for F-5 Gel, the active mixture of a new contraceptive sponge (Protectaid), which contains sodium cholate in association with low concentrations (0.5%) of nonoxynol-9 and benzalkonium chloride. Both cholic acid and the F-5 Gel exert a dose-dependent, in-vitro inhibitory effect (i) on the activity of HIV-1 associated reverse transcriptase in an acellular system and (ii) on the potential of HIV-1 efficiently to infect human lymphocytes.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

taurine, SodiumCholate, inhibit, Inhibitor, HepG2, HIV, HIV Protease, HIVProtease, Endogenous Metabolite, EndogenousMetabolite, glycine, cholesterol excretion, Cholic acid, Cholic acid sodium

Compound Identifiers

PubChem CID

23668194